I'm sorry this has been your experience, but it's been different here. I closed the VirtualBox manager that was open on its desktop on my laptop, and launched it again. As I did, I began counting off the seconds, and before I got to "two" it was up and running.
My eopkg history shows that mine was also upgraded from release 268 to 269 yesterday. I'll see if I can find out what was changed, but apparently it had no negative effect on my system. I would also like to hear from other VirtualBox users about this.
If you close VBox and restart the manager, does it open slowly the second time, too, or does it appear to be acting normally after that first experience?