WetGeek You've used this phrase several times recently. Is it Solus Plasma installed on a USB flash drive? Or a Solus "Live" session? Not long ago, I installed Solus on a 32GB USB flash drive, just to see if I could do that. Now I can't remember how well it worked, or what I did with it. It must not have been very impressive.
I have a complete, discrete and independent Solus Plasma build (EFI, swap and data partitions) on a PNY 256GB M.2 SATA drive enclosed in a Sabrent USB 3.2 Type-C enclosure for M.2 PCIe NVMe and SATA drives. The build is an exact replica of my in-laptop build (my login, my browser, my passwords, my apps, a copy of my monthly data backup, and so on), and I update regularly to keep the build current.
Using a short (6") C to C or C to A data cable, I can plug the enclosed drive into a USB-C or USB-A port on any UEFI computer (with Secure Boot disabled), boot from the UEFI Boot Menu, and I have a working computer running Solus Plasma as the OS/DE. When I unplug, I reboot the computer into its own OS (Windows typically). All I have to do is to remember to reset the date/time settings on the original OS. After I unplug and reset date/time, not a trace remains on the computer.
"Plasma on a Stick" is an extension of "dual drive, dual boot" installation, in which each OS drive stands on its own, entirely self-contained. The difference is that "Plasma on a Stick" deploys on an external drive rather than an internal drive. Otherwise, it is no different.
"Plasma on a Stick" works with Solus because Solus doesn't screw around with nonsense like Grub, but stands by itself alone. It probably would not work with distros using Grub, because Grub-based distros screw up the UEFI Boot Menu, but I wouldn't touch those distros anyway, except in a VM. I hate Grub.
I use "Plasma on a Stick" at the railroad on occasion (sometimes it is just easier to plug into a railroad computer than to get my laptop and fire it up), once in a while on a friend's computer, and sometimes on "public" computers. Right now it is a handy way to use the laptop until I get around to figuring out how I screwed up my in-laptop build and correcting it.
I think that straightening out the in-laptop build is going to be a mess, because that build does not see the speakers at all, which means I can't change the speaker profile. I'll spend an hour or two troubleshooting, but I'm probably in for a rebuild. I like Linux, but sometimes I'm ready to toss it out the window.
Edit/Update: Just for the record, there is nothing magic about using an external M.2 drive in an enclosure. I've created portable builds with 2.5" SATA drives in an enclosure. The advantage of M2. drivers is that the enclosures are smaller and easier to carry around and use.