I have both an AMD (primary) and Nvidia (secondary) graphics card on my system and the only 2 problems I face is that I can't render any 3D stuff on my Nvidia card, because apparently Nvidia needs xorg-server 1.21 (which is not released yet) to support PRIME Render Offload with the proprietary drivers, and that the NVIDIA X Server Settings application crashes if I don't have this line in my GPU .conf file inside /etc/X11/xorg.conf.d/: Option "AllowEmptyInitialConfiguration" inside Section "Device"
The only thing that seems to work in my Nvidia card for now is NVENC, which I use on OBS-Studio. But it may work fine for you if you use Nvidia as your primary card, I'm not sure.