I've been so happy with a change to one of my desktop machines that I wanted to share the idea with others who might want to try it:
https://c1.neweggimages.com/productimage/17-990-011-03.jpg?ex=2
This little device is simple to install in any external 3.5" bay, it's very affordable, and greatly expands the capabilities of one computer. It will mount two 2.5" drives in that bay, and allows them to be changed easily. All I needed to do was adjust the boot order to target these drives.
With this device I've been able to change this high-spec desktop machine into whatever kind of computer I want just by swapping a disk and rebooting. For Windows 10, I use two SSDs for drive C: and drive D:. And as cheap as 120 GB SSDs are these days, I can convert it to any flavor of Linux machine I want. That currently includes three flavors of Solus, as well as MX, Manjaro, Suse, Mint, and a few others.