Uninstalling things without things going up in flames, that's a new one. π
I would take a backup of your system, this is ALWAYS a good first step when making any system changes.
Then go through your applications menu, uninstall things you don't use or want any more.
Then run sudo eopkg remove-orphans
this will remove any packages that aren't depended on by another package. So if you install applicationA and it depends on libraryB and you remove applicationA. If libraryB isn't used by another application you can remove-orphans.