Generally fine. I just needed to go to the display settings and change the scaling to 200%. I also needed to zoom in on web pages a bit (i use my monitor more like a TV though. I sit further away.
Steam also has a hi-dpi setting that needs to be changed if you use it.
The only issue i have is that Icons on the bottom right (like the network and steam icon) will go missing when i switch the monitor off and back on. This didn't happen when i was using a 1080P monitor and 100% scaling. I think it has something to do with the scaling setting.
But other than that it works fine in my experience.