zmaint Wayland still does not have native proton/wine, still has issues with nvidia, and last I tried it has significant issues with context menus (as in it don't like to draw them).
The latest Wine releases builds the Wayland support by default, so it should now probably get more testing and developer attention. It still prefers XWayland when available, but this can be worked around (for testing purposes) by launching wine with DISPLAY= wine
to unset the display. I'm seeing some issues under Wayland though.
When it comes to NVIDIA I honestly notice no real difference between Wayland and X11 these days, except that the former feels smoother (on GNOME). Haven't experienced the context menu issue.
Oh yeah, the way notifications work is a bit annoying. Hopefully they can improve that some day.