As a newbie learning/shallowly experimenting with XFCE who has probably done many "experiments"/mistakes, I've noticed the panel profile didn't work from the menu (silently - nothing happens) or from the "more centrilized" settings/center/screen or control pannel, however it's called.
Today I had the idea of using the command line to try (with save), and noticed psutils or something like that is missing. installed psutils, this didn't solve the issue. then installed the python-psutil, voila it seems to work - both on the command like and GUI. (hadn't tested throughly, but it allegedly saves and a graphical instance can be opened as normally)
Noting that I don't know what was causing this and if it was so for the vanila solus XFCE installation, can't report accurately but wanted to note on a potencially missing dependency (I don't know accurately which) for panel-profiles on XFCE, a dependency somehow possibly related to python-psutil. (no idea if it's 100% sure and if it's so, if it's the single missing one)
Either way thank you very much for making a very nice Solus XFCE desktop for us