Have you tried switching your CPU scaling governor to performance prior to running Guitarix?
I switched to PipeWire way before it became default in Solus specifically because I didn't want to bother myself with setting up JACK anymore and honestly it's been smooth sailing since then (so far no real issues or xruns even at buffer size 64, though I've been using 128 lately).
Frankly, I didn't even change any configuration nor do I switch any audio profiles (really just using my Yamaha THR as both audio interface and monitor for guitar playing/practice and stuff). Couple things I do before running any audio app though:
Regarding the CPU governor (personally have aliases for this stuff and the pipewire latency in my .bashrc):
- To check which governor is your CPU set to currently:
cat /sys/devices/system/cpu/cpu*/cpufreq/scaling_governor
To actually change the governor use the cpupower
utility which you can get by installing the linux-tools-cpupower package.