So, as planned, I reset FF completely after the last sync, by deleting the .mozilla folder in home and the cache folder. To my great surprise, FF remains OTB light, without having modified anything in about:config, its performances are excellent, as much as before with the modified config (vaapi, webrender_all, x11....), I can see in about:support that almost everything is available by default for me.
Finally, less is more (?).