I 'm sure it's possible, but I don't personally know the details. I approach that problem differently.
Why not mount your second drive in a directory named something like "VMs" on your first drive, and use it to create a Windows 10 VM? That way, you don't need to close down all your Solus work in progress and reboot in order to chaange to Windows, and the same in reverse in order to return to Solus. That's what I do. I just have a single drive, but my Solus Plasma installation uses several VirtualBox VMs to give me access to Solus Budgie, Windows 10, and Windows 11 whenever I need one or more of the other systems.
I use the Windows 10 VM mainly to read eBooks with an application that's not available for Linux. I use the Windows 11 VM to familiarize myself with the new version of that system, and the Budgie VM to keep track of how that DE is maturing (it was my first love on Solus).
Each VM runs in a workspace, so changing from Solus (without shutting it down) to one of the other systems just requires a mouse click. Changing back to Solus just requires another click.
EDIT: Another useful advantage to VMs is that you can opt to share the clipboard between the host system and any of the virtual machines. And enable drag-n-drop between them. Thus, if I want to copy something from an application on Solus to a destination on Windows (or the other direction), I can do that as easily as if both the source and destination were on the same system. Sometimes that comes in really handy. Can't do that if you have to shut one system down in order to boot the other.
