Well, that didn't last long. Tested against a couple games (Elder Scrolls Online and Elite: Dangerous) using Proton (WINE) and got a bunch of crashes when using pipewire. After like the 4th crash on ESO, said screw it, swapped back over to pulseaudio, and no crashes since. 
Is Pipewire not fully supported on Solus?
13 days later
If you tried Pipewire/Wireplumber and switched back because they were buggy it's worth giving the updated versions (0.3.40/0.4.5 respectively) another try. WirePlumber as session manager was a bit rushed out the door to try to make the Fedora 35 release and was pretty buggy as a result. The new versions have a lot of fixes and should be far more stable for most people.
ReillyBrogan rushed out the door to try to make the Fedora 35 release and was pretty buggy as a result
slowclaps
5 days later
Last Pipewire/Wireplumber update borked PulseEffects for me, but after that I learned that EasyEffects is the new version with official Pipewire support. Downloaded EasyEffects via Flatpak and it worked out of the box again. So no problem with PulseEffects here, only want to mention it if someone else has the same case.
Just hit the bug where wireplumber dies after an update. Had to restart the service to get audio back.