cblade
Thanks for the hint on xrand. For me it worked with
xrandr --output DP-2-2-1 --rotate left.
My setup in short:
1st: Internal display turned off via settings.
2nd: Primary display (Lenovo P27-q10) then becomes display via DP-2-2-8 (weird name for me🙂
3rd: Daisychained DP-2-2-1 display (Eizo FlexScan L675) via dvi-adapter.
Best of all - the switch for changing the rotation in gnome gui is back in action after that.