brent I am interested in going towards compartmentalization in the future.
As happy as I am with Solus (and that hasn't changed at all), I routinely browse DistroWatch to see what's new. One thing I noticed today was EasyOS, based on Puppy. It made me think of you, because it provides the concept of "containers," in which a process can be run inside, or outside, of a container. The container gives each process its own copy of the / filesystem, so it's like a private sandbox. Lots of configuration available!
For me, it's not worth the time to download and install it, but I thought you might want to take a look because of your interest in compartmentalization.