I was curious if anyone had theirs disabled. I'm back to running it enabled right now after testing since I'm not doing anything that really benefits from running with or without it. The games I play don't act any different without it than with and am back to using my Intel Arc card for video encoding. The only virtual system I run is Windows 11 and that's about once a month or so for updating and a rare case I need to use the one Windows-based program that I still haven't found a perfect 100% linux-based version of yet.
As far as protecting against CPU attacks, I don't care about that. Don't visit any bad sites or run bad software that I shouldn't be running.
From my readings over the past couple of months, hyperthreading does come at a cost of an average of 30% performance on each core on the CPU since each core is jumping between 2 functions all the time. Some people have seen more but that all depends on the software your running.
I may go back to running non-hyperthreading in the future for when I need to do computational things like CPU based video encoding or graphics rendering.